| NMR Lecture notes |
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Spring School on Biomolecular Structure Determination
6th-8th June 2006, Leuven. [pdf-document]
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| Research |
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Content will be added soon.
In the meanwhile some selected publications: |
| Biomolecular NMR : structure function and interactions |
- Identification of the PXW Sequence as a Structural Gatekeeper of the HeadPiece C-terminal Subdomain Fold.
Vermeulen, W.; Van Troys, M.; Bourry, D.; Dewitte, D.; Rossenu, S.; Goethals, M., Borremans, F. A. M., Vandekerckhove, J., Martins, J. C. and Ampe C.
J. Mol. Biol. 359, 1277–1292 (2006).
- Solution structures of the C-terminal headpiece subdomains of human villin and advillin, evaluation of headpiece F-actin binding requirements.
Vermeulen, W.; Vanhaesebrouck, P.; Van Troys, M.; Verschueren, M.; Fant, F.; Goethals, M.; Ampe, C.; Martins, J. C. and Borremans, F. A. M.
Protein Science 13, 1276-1287 (2004).
- All intermediates of the arsenate reductase mechanism, including an intramolecular dynamic disulfide cascade.
Messens, J.; Martins, J. C.; Van Belle, K.; Brosens, E.; Desmyter, A.; De Gieter, M.; Wieruszeski, J.-M.; Willem, R.; Wyns, L and Zegers, I.
Proc. Natl. Acad. Sci. USA 99, 8506-8511 (2002).
- Arsenate reductase from S. Aureus plasmid pI258 is a phosphatase drafted for redox duty. Zegers, I.; Martins, J. C.; Willem, R.; Wyns, L. and Messens, J.
Nat. Struct. Biol. 8, 843-847 (2001).
- 1H NMR study of the Solution Structure of Ac-AMP2, a Sugar Binding Antimicrobial Protein Isolated from Amaranthus caudatus.
Martins, J. C.; Maes, D.; Loris, R.; Pepermans, H. A. M.; Wyns, L.; Willem R. and Verheyden, P.
J. Mol. Biol. 258, 322-333 (1996).
- 1H NMR Study of the Interaction of N,N',N”-triacetyl-chitotriose with Ac-AMP2, a Sugar Binding Antimicrobial Protein Isolated from Amaranthus caudatus.
Verheyden, P.; Pletinckx, J.; Maes, D.; Pepermans, H. A. M.; Wyns, L.; Willem, R. and Martins, J. C.
FEBS Lett. 370, 245-249 (1995).
- Determination of the Three-Dimensional Solution Structure of Scyllatoxin by 1H NMR.
Martins, J. C.; Van de Ven, F. J. M. and Borremans, F. A. M.
J. Mol. Biol. 253, 590-603 (1995).
- Solution Conformation of Leiurotoxin I (Scyllatoxin) by 1H NMR. Resonance Assignment and Secondary Structure.
Martins, J. C.; Zhang, W. and Borremans F. A. M.
FEBS Lett. 260, 249-253 (1990).
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Diffusion NMR Spectroscopy and its application in organic chemistry and the material sciences |
- Ligand Adsorption/Desorption at Sterically Stabilized InP Colloidal Nanocrystals: observation and thermodynamic analyis.
Moreels, I. ; Martins, J. C. and Hens, Z.
ChemPhysChem, 7, 1028-1031 (2006).
- An in situ 1H NMR view on the TOPO capping of colloidal InP nanocrystals.
Hens, Z.; Moreels, I. and Martins, J. C.
ChemPhysChem, ChemPhysChem 6, 2578-2584 (2005).
- In situ evaluation of interfacial affinity of CeO2 based hybrid nanoparticles by pulsed field gradient NMR.
Ribot, F.; Escax, V.; Roiland, C.; Sanchez, C.; Martins, J. C.; Biesemans, M.; Verbruggen, I. and Willem, R.
Chem. Comm. 1019-1021 (2005).
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NMR methods and techniques in organotin chemistry : development and application (as a postdoc with Prof. R. Willem, HNMR, Centre, Vrije Universiteit Brussel). |
- Fine-tuned characterization at the solid/solution interface of organotin compounds grafted on cross-linked polystyrene using high resolution MAS NMR spectroscopy.
Martins, J. C.; Mercier, F. A. G.; Vandervelden, A.; Biesemans, M.; Wieruszeski, J. M.; Humpfer, E.; Willem, R. and Lippens, G.
Chem. Eur. J. 8, 3431-3441 (2002).
- Tin NMR Based Methodologies and their Use in Structural Tin Chemistry.
Martins, J. C.; Biesemans, M. and Willem, R.
Prog. NMR Spectrosc. 36, 271-322 (2000).
- Modeling in Organotin Chemistry Using NMR Restraints: A Case Study on the 9R,12S[tBu 2 Sn]2O Derivative of Erythromycin A.
Martins, J. C.; Willem, R.; Mercier, F. A. G.; Gielen, M.; Biesemans, M.
J. Am. Chem. Soc. 121, 3284-3291 (1999).
- A Comparative Investigation of the Consistent Valence and Extensible Systematic Force Fields. A Case Study on the Conformation of Erythromycin A in Benzene.
Martins, J. C.; Willem, R. and Biesemans, M.
J. Chem. Soc., Perkin Trans. 2, 1513-1520 (1999).
- Optimal Detection of Weak n J( 1H- 119 Sn) Couplings by Gradient Enhanced 1D and 2D Heteronuclear Multiple-Quantum Correlation Spectroscopy. Application to a Novel Tin Derivative of Erythromycin A.
Martins, J. C.; Kayser, F.; Gielen, M.; Willem, R. and Biesemans, M.
J. Magn. Reson. 124, 218-222 (1997).
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Prof. dr. José C. Martins
+32 (0)9 264 44 69 |
Groupleader
Principle NMR Scientist |
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Katrien Haustraete
+32 (0)9 264 44 77
Ind. Ing. Chemie
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NMR operator
Currently in charge of all NMR services for the department of organic
chemistry and outside clients. Responsible for the Open Access on the
300 MHz. Principal technical support staff member for the highfield
equipment, including the 700 MHz from the INMRF.
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Tim Courtin
+32 (0)9 264 44 77
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n.a. |
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| Postdoctoral researchers |
Dr. Bernd Fritzinger
+32 (0)9 264 44 90
Ph. D in Chemistry
(Leibniz-IPF, Dresden, 2006)
Joined NMRSTRUC March 2006
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As 'Doctorassistent', in charge of the 700 MHz NMR facility for the UGent partner.
Research topics involve diffusion NMR spectroscopy and relaxation NMR
studies, both in materials (nanoparticles) and in proteins
(investigation of protein dynamics by NMR spectroscopy).
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Dr. Agnieszka Szczygiel
+32 (0)9 264 44 90
Ph.D in Physical Chemistry
(TU Vienna, 2003)
Joined NMRSTRUC October 2005 |
Assessment of the use of diffusion based NMR techniques for the characterisation of polymers and polymer ligand interactions and self assembling structures.
Project in collaboration with Dr. Frank Vangaever and Dr. Leo Timmermans of Agfa-Gevaert |
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PhD students |
David Bourry
+32 (0)9 264 44 88
Master in Biotechnology 2003
BOF-PhD grant
Joined NMRSTRUC February 2003
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Study of the interplay between structure and dynamics in the HeadPiece and Profilin actin binding proteins.
Project Funding : BOF-UGent
Project in collaboration with Dr. M. Van Troys and Prof. dr. C. Ampe, Department of Biochemistry and Medical Protein Research, Universiteit Gent. |
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Katelijne Gheysen
+32 (0)9 264 45 09
Master in Sciences, Chemistry 2006
GOA-PhD grant
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Development and application of NMR techniques for the study of
host-guest interactions, with emphasis on diffusion spectroscopy and
application towards the development of artificial receptors for
endocrine disrupting chemicals.
Project Funding: GOA-grant within the Department of Organic Chemistry (P. Sandra, Promotor).
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Pieter Hendrickx
+32 (0)9 264 44 88
Master in Sciences, Chemistry 2004
IWT-SBO grant
Joined NMRSTRUC in April 2005 |
Peptide- and Protein Mimetics: A Combinatorial Approach using Priviliged Templates: Development of a Queriable Database of Conformations from Experimental Data using NMR and Molecular Modelling.
Project Funding : IWT-SBO
SBO-Project involving Prof. dr. J. Van der Eycken, UGent, Prof. E. Van der Eycken, KULeuven, Prof. dr. A. Haemers and Prof. dr. K. Augustyns, UA and Prof. dr. R. Willem and Prof. dr D. Tourwé (promoter-coordinator), VUB |
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Davy Sinnaeve
+32 (0)9 264 45 09
Master in Sciences, Chemistry 2005 Aspirant FWO
Joined NMRSTRUC October 2005 |
Development and application of diffusion based Magnetic Resonance techniques for the study of biofluids and intermolecular interactions.
Project Funding : No additional funding
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Bjorn Van Gasse
+32 (0)9 264 45 09
Master in Sciences, Chemistry 2006
Teaching assistant
Joined NMRSTRUC October 2006 |
Application of NMR in metabonomic profiling of blood plasma
and cerebrospinal fluids.
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Undergraduate students |
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| Collaborations |
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| Collaborative Research Partners within the Universiteit Gent : |
Department of Physical Organic Chemistry, Faculty of Sciences |
Prof. dr. Zeger Hens
Ir. Iwan Moreels |
In this collaboration, the use of NMR spectroscopy and diffusion NMR techniques is being explored in order to characterize colloidal dispersions of capped semi-conductor nanocrystals from the capping ligand's point of view. |
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Department of Molecular Biotechnology, Faculty of Bioscience Engineering |
Prof. dr. W. Van Criekinge
Dr. Ir. Sofie Bekaert
Ir. Tim De Meyer
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Collaboration to integrate NMR spectroscopy for metabonomic profiling of blood for biomedical research.
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External Collaborative Research Partners: |
High-resolution NMR Centre, Vrije Universiteit Brussel |
Prof. dr. R. Willem
Prof. dr. M. Biesemans
Ir. Ingrid Verbruggen
Dr. Camelia Mihai
Kevin Poelmans
Vanja Pinoie |
As a former postdoctoral fellow of the HNMR Centre of the VUB in the period 1994-2002, a very close collaboration continues to date between the NMRSTRUC of J. Martins and the HNMR group of R. Willem.
Application of hr-MAS NMR as well as DOSY NMR measurements, developed during the stay of J. Martins in the HNMR group are the object of a continued and close collaboration with Prof. R. Willem. This collaboration involves mutual access to the respective NMR facilities and exchange of probeheads between the 500 MHz instruments.
In addition, the group is co-applicant and user of the INMRF 700 MHz NMR facility. |
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UMR 8525, NMR laboratory, Institut Pasteur de Lille, France |
Prof. Dr. Ir. Guy Lippens
Ir. Jean-M ichel Wieruszeski |
Following a 1 year postdoctoral stay in 2001 at the NMR Lab of Prof. Guy Lippens, a continued collaboration has existed in the field of biomolecular NMR, with the possibility to access the 600 MHz + cryoprobe and 800 MHz NMR facilities. |
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Kemin Pharma Europe |
Dr. Benedikt Sas
Dr. Johan van Hemel |
Research collaboration in the use of NMR for structure elucidation of newly isolated natural compounds with potentially interesting biological activity. |
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Glaxo Smith Kline Biologicals |
Dr. Karel Conrath |
Research collaboration in the structure elucidation and confirmation of capsular polysaccharides. |
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Agfa Gevaert N.V. |
Dr. F. Van Gaever,
Dr. L. Timmermans
Dr. E. Mannekens
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Joint research project to develop the application of diffusion NMR based techniques for the physicochemical characterisation of polymer stabilised dispersions. |
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| Biography |
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Education and Scientific carreer
1984-1988 Universiteit Gent, Faculty of Sciences, Master in Science, Chemistry
- Graduated summa cum laude , with a major in Organic Chemistry.
Master thesis with Prof. M. J. O. Anteunis :
- A preliminary investigation towards the semi-synthesis of Virginiamycin S.
1988–1993 Universiteit Gent, Department of Organic Chemistry, Biomolecular NMR unit, Ph.D research with Prof. Frans Borremans
- 1988-1989 Scientific Research Assistant.
- 1989-1993 Research Assistant with National Fund for Scientific Research (N.F.W.O.)
- 1993 : Ph.D in Sciences, Chemistry, summa cum laude.
The determination with nuclear magnetic resonance of the three-dimensional structure of Scyllatoxine, a small protein from scorpion venom .
1993-1994 Institut International Chimie–Physique–Solvay, Brussel and Department of Organic Chemistry (ORGC), Vrije Universiteit Brussel, with Prof. George Van Binst, NMR postdoctoral fellow
1994-2002 Vrije Universiteit Brussel, High Resolution NMR Centre, with Prof. Rudi Willem, postdoctoral research in Protein and Organotin NMR
- 1994-1997 Postdoctoral Fellow of the VUB
- 1997-2002 Postdoctoral Fellow of the FWO-Vlaanderen
2001 1 year member of the NMR Laboratory of the UMR 8525, Institut Pasteur de Lille, with Prof. Guy Lippens
2002-now Universiteit Gent, Department of Organic Chemistry, NMR and Structure Analysis Unit
- 2002-now Hoofddocent (Assistant Professor)
Activities and Appointments
Coordinator of the Interuniversitary NMR Facility hosting the high field 700 MHz.
Member and Secretary of the FWO Scientific Research Network:
Advanced Applications of Nuclear Magnetic Resonance to the Chemical, Material and Biomedical Sciences (since 2002).
Co-organizer with Prof. M. Luhmer (Université Libre de Bruxelles) of the annual Young Belgian Magnetic Resonance Scientist Symposium. (since 2003)
Member of the National Committee for Biophysics. (since 2004)
Member of the Organizing Committee of the French-Benelux NMR meeting in Blankenberge, March 16th-19th 2005.
2002-2004: Member of the Education Board of Chemistry.
Member of the following societies:
Belgian Biophyscial Society;
Belgian Biochemical and Molecular Biology Society;
American Chemical Society;
Association for the Advancement of Science.
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| Publications |
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| 2007 |
publications | top |
- Characterization of titanium dioxide nanoparticles dispersed in organic
ligand solutions using a diffusion ordered spectroscopy based strategy.
Van Lokeren, L., Maheut,G., Ribot,F., Escax, V., Verbruggen,I.,
Sanchez,C., Martins,José C., Biesemans, M. and Willem, R.
Chem. Eur. J. in press (2007).
- Solution NMR techniques for investigating colloidal nanocrystal ligands:
A case study on trioctylphosphine oxide at InP quantum dots
Moreels, I., Martins, J.C. and Hens, Z.
Sensors and Actuators B, in press (2007).
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| 2006 |
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- Synthesis and Biological Evaluation of Bicyclic Nucleosides as Inhibitors of M. tuberculosis Thymidylate Kinase.
Van Daele, I., Munier-Lehmann, H., Hendrickx , P., Froeyen, M., Rozenski, J., Qing, L., Martins, J. C., Van Calenbergh, S.
ChemMedChem in press (2006).
- Solid-Supported Synthesis of Highly Functionalized Tripodal Peptides with Flexible but Preorganized Geometry: Towards Potential Serine Protease Mimics
Gea, A., Roqué i Rossell, N., Farcy, N., Martins, J. C., Madder, A. and De Clercq , P.J., Eur. J. Org. Chem.,
18, 4135-4146 (2006).
- Ligand Adsorption/Desorption at Sterically Stabilized InP Colloidal Nanocrystals: observation and thermodynamic analyis.
Moreels, I.; Martins, J. C. and Hens, Z.
ChemPhysChem,7, 1028-1031 (2006)
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- Identification of the PXW Sequence as a Structural Gatekeeper of the HeadPiece C-terminal Subdomain Fold.
Vermeulen, W.; Van Troys, M.; Bourry, D.; Dewitte, D.; Rossenu, S.; Goethals, M., Borremans, F. A. M., Vandekerckhove, J., Martins, J. C. and Ampe C.
J. Mol. Biol., 359, 1277–1292 (2006).
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| 2005 |
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- An in situ 1H NMR view on the TOPO capping of colloidal InP nanocrystals.
Hens, Z.; Moreels, I. and Martins, J. C.
ChemPhysChem 6, 2578-2584 (2005).
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Polystyrene-Supported Organotin Dichloride as a Recyclable Catalyst in Lactone Ring-Opening Polymerization: Assessment and Catalysis Monitoring by High-Resolution Magic-Angle-Spinning NMR Spectroscopy.
Deshayes, G.; Poelmans, K.; Verbruggen, I.; Camacho-Camacho, C.; Degée, P.; Pinoie, V.; Martins, J. C.; Piotto, M.; Biesemans, M.; Willem, R. and Dubois, P.
Chem. Eur. J. 11, 4550-4559 (2005).
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In situ evaluation of interfacial affinity of CeO2 based hybrid nanoparticles by pulsed field gradient NMR.
Ribot, F.; Escax, V.; Roiland, C.; Sanchez, C.; Martins, J. C.; Biesemans, M.; Verbruggen, I. and Willem, R.
Chem. Comm. 1019-1021 (2005).
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How Thioredoxin can reduce a buried disulfide bond.
Messens, J.; Van Molle, I.; Vanhaesebrouck, P.; Limbourg, M.; Van Belle, K.; Wahni , K.; Martins , J. C.; Loris , R. and Wyns , L.
J. Mol. Biol. 339, 527-537 (2004).
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The structure of a triple mutant of pI258 arsenate reductase from Staphylococcus aureus and its 5-thio-2-nitrobenzoic acid adduct.
Messens, J.; Van Molle, I.; Vanhaesebrouck, P.; Van Belle, K.; Wahnia, K.; Martins, J. C.; Wyns, L. and Loris, R.
Acta Cryst. D 60, 1180-1184 (2004).
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Solution structures of the C-terminal headpiece subdomains of human villin and advillin, evaluation of headpiece F-actin binding requirements.
Vermeulen, W.; Vanhaesebrouck, P.; Van Troys, M.; Verschueren, M.; Fant, F.; Goethals, M.; Ampe, C.; Martins, J. C. and Borremans, F. A. M.
Protein Science 13, 1276-1287 (2004).
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Interface Synthesis, Characterization and Catalytic Properties of Dialkyldichlorotin and Tetra-alkyl Distannoxane Functionalities Grafted to Insoluble Polystyrene Beads by a Hexamethylene Spacer.
Biesemans, M.; Mercier, F. A. G.; Van Poeck, M.; Martins, J. C.; Dumartin, G. and Willem, R.
Eur. J. Inorg. Chem. 2908-2913 (2004).
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Assessing weak intramolecular donor-acceptor interactions using 1H- 117 Sn J-HMQC spectroscopy.
Biesemans, M.; Martins, J. C.; Jurkschat, K.; Pieper, N.; Seemeyer, S. and Willem, R.
Magn. Res. Chem. 42, 776-780 (2004).
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Probing Ionic Association on Metal Oxide Clusters by Pulsed field Gradient NMR : the Example of tin-12 Oxo-Clusters.
Ribot, F.; Escax, V.; Martins, J. C.; Biesemans, M.; Ghys, L.; Verbruggen I. and Willem, R.
Chem. Eur. J. 10, 1747-1751 (2004).
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- Ab initio study of the binding of Trichostatin A (TSA) in the active site of Histone Deacetylase Like Protein (HDLP).
Vanommeslaeghe, K.; Van Alsenoy, C.; De Proft, F.; Martins, J. C.; Tourwé, D. and Geerlings, P.
Org. Biomol. Chem. 1, 2951-2957 (2003).
- Structure Characterization of the Products of the Reaction between Racemic 1,2,4-Butane Triol and Di-tert-butyltin Oxide.
Biesemans, M.; Buytaert, G.; Van Lokeren, L.; Martins J. C.; Willem, R. and Tiekink E.R.T.
Organometallics 22 , 1888-1893 (2003).
- urification of an oxidation sensitive enzyme, pI258 arsenate reductase from Staphylococcus aureus.
Messens, J.; Martins, J. C.; Zegers, I.; Van Belle, K.; Brosens, E. and Wyns, L.
J. Chromat. B. 790, 217-227 (2003).
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Publications as a postdoctoral researcher at the VUB (1993-2002) |
2002 |
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- All intermediates of the arsenate reductase mechanism, including an intramolecular dynamic disulfide cascade.
Messens, J.; Martins, J. C.; Van Belle, K.; Brosens, E.; Desmyter, A.; De Gieter, M.; Wieruszeski, J.-M.; Willem, R.; Wyns, L and Zegers, I.
Proc. Natl. Acad. Sci. USA 99, 8506-8511 (2002).
- Fine-tuned characterization at the solid/solution interface of organotin compounds grafted on cross-linked polystyrene using high resolution MAS NMR spectroscopy.
Martins, J. C.; Mercier, F. A. G.; Vandervelden, A.; Biesemans, M.; Wieruszeski, J. M.; Humpfer, E.; Willem, R. and Lippens, G.
Chem. Eur. J. 8, 3431-3441 (2002).
- Active Site Loop Dynamics and Protein Stability Kinetics of S. aureus Arsenate Reductase.
Messens, J.; Martins, J. C.; Brosens, E.; Van Belle, K.; Jacobs, D. M.; Willem, R.
and Wyns, L.
J. Biol. Inorg. Chem . 7, 146-156 (2002).
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- Arsenate reductase from S. Aureus plasmid pI258 is a phosphatase drafted for redox duty.
Zegers, I.; Martins, J. C.; Willem, R.; Wyns, L. and Messens, J.
Nat. Struct. Biol. 8, 843-847 (2001).
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Complexation of Triorganotin Derivatives of 4-Carboxybenzo-18-Crown-6 and -15-Crown-5 with Alkali Thiocyanates.
Tsagatakis, J.; Chaniotakis, N.; Altmann, R.; Jurkschat, K.; Martins, J. C.; Willem, R.; Qiu, Y. and Bakker, E.
Helv. Chim. Acta 84, 1952-1961 (2001).
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Phosphate-Binding Characteristics and Selectivity Studies of Bifunctional Organotin Carriers.
Kemmer, M.; Biesemans, M.; Gielen, M.; Martins, J. C.; Gramlich, V. and Willem, R.
Chem. Eur. J. 7, 4686-4695 (2001).
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1H, 13C and 15N Backbone Resonance Assignment of the Arsenate Reductase from Staphylococcus aureus in its Reduced State.
Jacobs, D. M.; Messens, J.; Wechselberger, R.; Brosens, E.; Willem, R.; Wyns, L. and Martins, J. C.
J. Biomol. NMR 20, 95-96 (2001).
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Solution Structure of the Main a -Amylase Inhibitor from Amaranth seeds.
Martins, J. C.; Enassar, M.; Willem, R.; Wieruszeski, J.-M.; Lippens, G. and Wodak, S. J.
Eur. J. Biochem. 269, 2379-2389 (2001).
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Unprecedented Sigmatropic Rearrangements leading to 2,3-Dihydro-1H-2-Benzazepine-3-Carboxylic acid.
Martins, J. C.; Van Rompaey, K.; Wittmann, G.; Tömböly, C.; Toth, G.; De Kimpe, N. and Tourwé, D.
J. Org. Chem. 66, 2884-2886 (2001).
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Di-n-Butyl Methyl- and Phenylphosphonates.
Ribot, F.; Sanchez, C.; Biesemans, M.; Mercier, F. A. G.; Martins, J. C.; Gielen, M. and Willem, R.
Organometallics 20, 2593-2603 (2001).
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- Dibutyltin Perfluoroalkanecarboxylates: Synthesis, NMR Characterization and in vitro Antitumor Activity.
Kemmer, M.; Dalil, H.; Biesemans, M.; Martins, J. C.; Mahieu, B.; Horn, E.; de Vos, D.; Tiekink, E. R. T.; Willem, R. and Gielen, M.
J. Organomet. Chem. 608, 286-290 (2000).
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Convenient Synthesis of 3,4-Methano-1,2,3,4- Tetrahydro-isoquinoline-3-Carboxylic Acid and its Derivatives as Double Constrained Nonproteinogenic amino acid derivatives. Csombos, J.; Aelterman, W.; Tkachev, A.; Martins, J. C.; Péter, A.; Toth, G.; Fülöng, F.; Tourwé, D. and De Kimpe N.
J. Org. Chem. 65, 5469-5475 (2000).
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Reaction of BuSnO(OH) with p-toluenesulfonic acid: Synthesis, X-ray crystal Analysis and Multinuclear NMR Characterization of {(BuSn)12O14(OH)6}(PTS)2(PTS: p-toluenesulfonate).
Eychenne-Baron, C.; Ribot, F.; Steunou, N.; Sanchez, C.; Fayon, F.; Biesemans, M.; Martins, J. C. and Willem, R.
Organometallics 19, 1940-1949 (2000).
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Tin NMR Based Methodologies and their Use in Structural Tin Chemistry.
Martins, J. C.; Biesemans, M. and Willem, R.
Prog. NMR Spectrosc. 36, 271-322 (2000).
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13C-119Sn Correlation NMR in Solution and 119Sn-13C CP/MAS NMR Spectra of Dibutyltin(IV) and Bis(tributylstannyl(IV)) L-(+) Ascorbates and O-5,6-Isopropylidene-L(+)-Ascorbates.
Lycka, A.; Micak, D.; Holecek, J.; Biesemans, M.; Martins, J. C. and Willem, R.
Organometallics 19, 703-706 (2000).
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Multinuclear 1D and 2D NMR Investigations on the Interaction between the Pyrimidic nucleotides 5'-CMP, 5'-dCMP and 5'-UMP and Diethyltin Dichloride in Aqueous Medium. Ghys, L.; Biesemans, M.; Gielen, M.; Garoufis, A.; Hadjiliadis, N.; Willem, R. and Martins, J. C.
Eur. J. Inorg. Chem. 513-522 (2000).
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- The Reaction of Di-n-butyltin Oxide with Hexafluoro-2,2-bis(4-carboxyphenyl)propane.
Willem, R.; Dalil, H.; Biesemans, M.; Martins, J. C. and Gielen, M.
Appl. Organometal. Chem. 13, 605-608 (1999).
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A Comparative Investigation of the Consistent Valence and Extensible Systematic Force Fields. A Case Study on the Conformation of Erythromycin A in Benzene.
Martins, J. C.; Willem, R. and Biesemans, M.
J. Chem. Soc., Perkin Trans. 2, 1513-1520 (1999).
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Tributyl- and Triphenyltin Benzoates, Phenylacetates and Cinnamates as Anion Carriers: an Electrochemical Assessment Coupled to Structural NMR Studies and AM1 Calculations.
Tsagatakis, J. K.; Chaniotakis, N. A.; Jurkschat, K.; Damoun, S.; Geerlings, P.; Bouhdid, A.; Gielen, M.; Verbruggen, I.; Biesemans, M.; Martins, J. C. and Willem, R.
Helv. Chim. Acta 82, 531-542 (1999).
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Modeling in Organotin Chemistry Using NMR Restraints: A Case Study on the 9R,12S[tBu 2 Sn] 2 O Derivative of Erythromycin A.
Martins, J. C.; Willem, R.; Mercier, F. A. G.; Gielen, M.; Biesemans, M.
J. Am. Chem. Soc. 121, 3284-3291 (1999).
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A Gene Encoding a Hevein-Like Protein from Elderberry (Sambucus nigra) Fruits is Homologous to PR-4 and Class V Chitinase Genes.
Van Damme, E. J. M.; Charels, D.; Roy, S.; Tierens, K.; Barre, A.; Martins, J. C.; Rougé, P.; Van Leuven, F.; Does, M. and Peumans, W.
Plant Physiol. 119, 1547-1556 (1999).
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- Synthesis and Structure of Di-n-Butyltin-Pyridine-2-phosphonate-6-carboxylate.
Gielen, M.; Dalil, H.; Ghys, L.; Boduszek, B.; Tiekink, E. R. T.; Martins, J. C.; Biesemans, M. and Willem, R.
Organometallics 17, 4259-4262 (1998).
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Reconsidering the Energetics of Ribonuclease Catalysed RNA hydrolysis.
Loverix, S.; Laus, G.; Martins, J. C.; Wyns, L. and Steyaert, J.
Eur. J. Biochem. 257, 286-290 (1998).
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Reactions of [t-Bu2SnO]3 with [t-Bu2X2Si]2 (X= F,Cl). Synthesis and Structure of Novel Stannasiloxanes and of [(t-Bu2FSn)2O]2 , the first Fluorine-Containing Tetraorganodistannoxane.
Beckmann, J.; Biesemans, M.; Hassler, K.; Jurkschat, K.; Martins, J. C.; Schürmann, M. and Willem, R.
Inorg. Chem. 37, 4891-4897 (1998).
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Solution and Solid State Multinuclear NMR investigation of the Structure of {(BuSn)12O14 (OH)6}(O2PPh2)2.
Ribot, F.; Sanchez, C.; Willem, R.; Martins, J. C. and Biesemans, M.
Inorg. Chem. 37, 911-917 (1998).
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- Synthesis and Solution State Characterisation by Gradient Enhanced 2D Multinuclear NMR Spectroscopy of a Fluorine-Bridged Dimethyltin(IV) Salicylaldoximate Derivative.
Meddour, A.; Mercier, F.; Martins, J. C.; Gielen, M.; Biesemans, M. and Willem, R.
Inorg. Chem. 36, 5712-5715 (1997).
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Synthesis, Molecular Structure, and Stereochemical Nonrigidity of Bis(3-(dimethylamino)propyl)difluorostannane Dihydrate, {[Me2N(CH2)3]2SnF2.2H2O} and Enhanced Reactivity of Its Fluoride Adduct {[Me2N(CH2)3]2SnFs}-Bu4N+ toward Dichloromethane.
Pieper, N.; Klaus-Mrestani, C.; Schürmann, M.; Jurkschat, K.; Biesemans, M.; Verbruggen, I.; Martins, J. C. and Willem, R.
Organometallics 16, 1043-1052 (1997).
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Optimal Detection of Weak nJ(1H-119Sn) Couplings by Gradient Enhanced 1D and 2D Heteronuclear Multiple-Quantum Correlation Spectroscopy. Application to a Novel Tin Derivative of Erythromycin A.
Martins, J. C.; Kayser, F.; Gielen, M.; Willem, R. and Biesemans, M.
J. Magn. Reson. 124, 218-222 (1997).
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Solution Conformation of Raphanus sativus Antifungal Protein 1 (Rs-AFP1) by 1H Nuclear Magnetic Resonance. Resonance Assignment, Secondary Structure and Global Fold.
Fant, F.; Vranken, W. F.; Boulez, K.; Martins, J. C. and Borremans, F. A. M.
Bull. Soc. Chim. Belg. 106, 51-57 (1997).
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- 1H NMR study of the Solution Structure of Ac-AMP2, a Sugar Binding Antimicrobial Protein Isolated from Amaranthus caudatus.
Martins, J. C.; Maes, D.; Loris, R.; Pepermans, H. A. M.; Wyns, L.; Willem R. and Verheyden, P.
J. Mol. Biol. 258, 322-333 (1996).
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Conformational Features of a Synthetic Cyclic Peptide Corresponding to the Complete V3 Loop of the RF-HIV-1 Strain in Water and Water/Trifluoroethanol Solutions.
Vranken, W. F.; Budesinsky, M.; Martins, J. C.; Fant, F.; Boulez, K.; Gras-Masse, H. and Borremans, F. A. M.
Eur. J. Biochem. 236, 100-108 (1996).
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Synthesis and Characterization of Triphenyl- and Tri-n-butyltin Pentafluoro benzoates, -Phenylacetates and -Cinnamates. X-ray Structure Determination of Tri-n-butyltin Pentafluorocinnamate.
Willem, R.; Bouhdid, A.; Biesemans, M.; Martins, J. C.; De Vos, D.; Tiekink, E. R. T. and Gielen, M.
J. Organomet. Chem. 514, 203-212 (1996).
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1H NMR Study on the Inclusion of Bicyclo[3.3.1]nonanes in cyclodextrins.
Butkus, E.; Martins, J. C. and Berg U.
J. Incl. Phenom. Mol. 25, 125-128 (1996).
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X-ray Diffraction and 2D 1H-119Sn Gradient Assisted HMQC NMR Studies on the Structure of Condensation Complexes of Salicylaldoxime and Dimethyltin(IV) oxide.
Willem, R.; Bouhdid, A.; Kayser, F.; Delmotte, A.; Gielen, M.; Martins, J. C.; Biesemans, M.; Mahieu, B. and Tiekink, E. R. T.
Organometallics 15, 1920-1929 (1996).
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1H NMR Spectroscopic Study of the Interaction between Cyclodextrins and Bicyclo[3.3.1]nonanes.
Butkus, E.; Martins, J. C. and Berg U.
J. Incl. Phenom. Mol. 26, 209-218 (1996).
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- 1H NMR Study of Inclusion of Substituted Bicyclo[3.3.1]nonanes in alpha- and beta-Cyclodextrins.
Butkus, E. P. and Martins, J. C.
Russ. Chem. Bull. 44, 2420-2422 (1995).
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1H NMR Study of the Interaction of N,N',N”-triacetyl-chitotriose with Ac-AMP2, a Sugar Binding Antimicrobial Protein Isolated from Amaranthus caudatus.
Verheyden, P.; Pletinckx, J.; Maes, D.; Pepermans, H. A. M.; Wyns, L.; Willem, R. and Martins, J. C.
FEBS Lett. 370, 245-249 (1995).
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A Comparative Structural Study on the Steroids [1,2,5]Oxadiazolo[3',4':3,4]-5-alpha-pregn-16-en-20-one oxime (HS998), [1,2,5]Oxadiazolo[3',4':3,4]-5-alpha-pregn-16-en-20-one (HS974) and [1,2,5]Oxadiazolo[3',4':3,4]-5-beta-pregn-16-en-20-one oxime (HS973) by NMR, Molecular Modeling and X-ray Investigations.
Kayser, F.; Maes, D.; Wyns, L.; Lisgarten, J.; Palmer, R.; Lisgarten, D.; Willem, R.; Martins, J. C.; Verheyden, P. and Biesemans, M.
Steroids 60, 713-719 (1995).
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Publications resulting from the PhD period at the UGent (1988-1993) |
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- Determination of the Three-Dimensional Solution Structure of Scyllatoxin by 1H NMR.
Martins, J. C.; Van de Ven, F. J. M. and Borremans, F. A. M.
J. Mol. Biol. 253, 590-603 (1995).
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Solution Conformation of Leiurotoxin I (Scyllatoxin) by 1H NMR. Resonance Assignment and Secondary Structure.
Martins, J. C.; Zhang, W. and Borremans F. A. M.
FEBS Lett. 260, 249-253 (1990).
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Isolation and Characterisation of Mutumol, 22-acetoxy-3 b ,23-dihydroxy-24-methylene-lanost-8-ene, from the East African Fungus Pisolithus Arhizus (Pers.) Rausch.
Van Puyvelde, L.; De Kimpe, N.; Vanderick, F.; Costa, J.; Niyotwagira, V.; Borremans, F.; Martins, J.; Declercq, J.-P. and Schamp, N.
Bull. Soc. Chim. Belg. 97, 901-909 (1988).
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| NMR Solvents (http://www.chem.wisc.edu/areas/reich/Handouts/nmr/NMR-Solvents.htm) |
